Mendelian randomization analysis of blood uric acid and risk of preeclampsia: based on GWAS and eQTL data

作者：Jiao Wang, Xiaohu Liu, Yuting Fu, Baosheng Zhu, Jinman Zhang · 发表于：The Journal of Maternal-Fetal & Neonatal Medicine · 年份：2025 · DOI：10.1080/14767058.2024.2443673 · 被引用次数：2 · 研究领域：Pregnancy and preeclampsia studies、Gout, Hyperuricemia, Uric Acid、Genetic Associations and Epidemiology

Background The causal association between blood uric acid and preeclampsia (Preeclampsia, PE) has not been conclusively established based on the literature reviewed to date. This bi-directional Mendelian randomization study aimed to investigate the bi-directional causal association between blood uric acid concentration and PE at different genetic levels.Methods Pooled data on preeclampsia (sample size = 82,085) and blood uric acid (sample size = 129,405) were conducted based on publicly available genome-wide association analysis (Genome-Wide Association Study, GWAS) on the East Asian populations regarding preeclampsia and blood uric acid, respectively. We assessed blood uric acid and PE associations using two-sample Mendelian randomization (TSMR) analyses based on GWAS pooled statistics using inverse variance weighted (Inverse variance weighted), MR-Egger, and Weighted median (Weighted median) to examine the association between blood uric acid and pre-eclampsia. Causal relationship between blood uric acid and pre-eclampsia.Cochran’s Q statistic was used to quantify the heterogeneity of instrumental variables among other methods. Subsequently, we extracted the expression quantitative trait loci (eQCTL, Expression quantitative trait loci) data corresponding to each gene as the instrumental variables using the genes corresponding to the intersecting instrumental variables of the exposure and the outcome in the respective analyses of the forward and backward TSMR respectively, so...