RED BLOOD CELL DISTRIBUTION WIDTH: FURTHER INSIGHTS

作者：Matt T. Oberdier, Marta Zampino, Michelle Shardell, Majd AlGhatrif, Edward G. Lakatta, Eleanor M. Simonsick, Luigi Ferrucci · 发表于：Innovation in Aging · 年份：2024 · DOI：10.1093/geroni/igae098.4062 · 被引用次数：1 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Digital Imaging for Blood Diseases、Blood properties and coagulation

Abstract Red blood cell distribution width (RDW) measures erythrocyte size variability and strongly predicts cardiovascular disease (CVD) morbidity and mortality. Our prior cross-sectional analysis showed that inflammation, metabolic rate, and body habitus are independently associated with RDW. To better understand determinants of RDW, we performed a longitudinal analysis associating changes in RDW within the normal range (11.5 - 15.0%) with age, sex, race, and changes in other erythrocyte properties, major CVD risk factors, and other physiologic measures. Data were from 452 men and 482 women, aged 50 to 94 years enrolled in the Baltimore Longitudinal Study of Aging. For each participant and each predictor, change was the regression coefficient of time from a linear model. Coefficients of candidate correlates were then used to predict change in RDW in multiple linear regression models that were reduced by backward selection. In the final model, increasing erythrocyte number (STβ=1.4980, P< 0.001), mean platelet volume (STβ=0.2019, P< 0.001), anion gap (STβ=0.1754, P< 0.001), blood urea nitrogen (STβ=0.0684, P=0.0395), urine albumin-creatinine ratio (STβ=0.1007, P=0.0015), alanine transaminase (STβ=0.1580, P< 0.001), interleukin-6 (STβ=0.2338, P< 0.001), and diastolic blood pressure (STβ=0.0769, P=0.0107) and decreasing glucose (STβ=-0.2425, P< 0.001), vitamin B12 (STβ=-0.1310, P< 0.001), and C-reactive protein (STβ=-0.1801, P&a...