Ultrasound-activated erythrocyte membrane-camouflaged Pt (II) layered double hydroxide enhances PD-1 inhibitor efficacy in triple-negative breast cancer through cGAS-STING pathway-mediated immunogenic cell death

作者：Yanjie Wu, Zhiyu Zhao, Mengli Ma, Weijin Zhang, Wei Liu, Xiaochen Liang, Ting Zhao, Yi Luo, Yunjie Wang, Mengqi Li, Tingting Li, Cong Liu, Xian Luo, Shengyu Wang, Wanyun Li, Wei‐Cai Zeng, Hong Wang, Wengang Li, Ting Wu, Zhihai Ke, Fanghong Luo · 发表于：Theranostics · 年份：2024 · DOI：10.7150/thno.102284 · 被引用次数：24 · 研究领域：Nanoplatforms for cancer theranostics、Peptidase Inhibition and Analysis、Ga2O3 and related materials

The integration of RmPLH with PD-1 inhibitors substantially amplifies ICD, fostering robust antigen-specific T cell immunity and offering a promising therapeutic strategy for TNBC. This study represents a pioneering application of Pt (II)-based LDH nanocages in oncology, laying a foundation for future innovations in tumor immunotherapy.