ADL+: A Digital Toolkit for Multidomain Cognitive, Physical, and Nutritional Interventions to Prevent Cognitive Decline in Community-Dwelling Older Adults

作者：Justin Chew, Zhiwei Zeng, Toh Hsiang Benny Tan, Pamela Chew, Noorhazlina Ali, Hao Wang, Melissa Ong, Roslyn Raymond, Kalene Pek, Di Wang, Liang Zhang, Zhiqi Shen, Cyril Leung, Jing Jih Chin, Wee Shiong Lim, Chunyan Miao · 发表于：International Journal of Environmental Research and Public Health · 年份：2024 · DOI：10.3390/ijerph22010042 · 被引用次数：6 · 研究领域：Dementia and Cognitive Impairment Research、Technology Use by Older Adults、Intensive Care Unit Cognitive Disorders

BACKGROUND: Current research highlights the importance of addressing multiple risk factors concurrently to tackle the complex etiology of dementia. However, limited evidence exists on the efficacy of technology-driven, multidomain community-based interventions for preventing cognitive decline. OBJECTIVES: To evaluate the efficacy of ADL+, an artificial intelligence (AI)-enabled digital toolkit integrating cognitive assessments and multidomain interventions, on outcomes of cognitive function, activity levels, and quality of life in older adults at risk of cognitive decline. Adherence and usability were also evaluated. METHODS: We conducted a quasi-experimental study including community-dwelling older adults aged 60 years and above without dementia, but with subjective memory complaints (AD8 score ≥ 2). Participants received a six-month intervention (app-based cognitive training, personalized nutritional, physical, and social activities recommendations) or a control group treatment (cognitive health educational package). The primary outcome was a change in neuropsychological test battery (NTB) Z-scores (NTB composite and its individual domains: attention, processing speed, memory, and executive function). Secondary outcomes were activity levels (Frenchay Activities Index, FAI), and quality of life (EQ-5D). Outcomes were assessed at the end of the intervention and three months post-intervention using linear mixed-effects models. RESULTS: 96% of participants in the intervention a...