Epidermal Penetration Increases with Age and May Contribute to Systemic Inflammation

作者：T Richard Parenteau, Anna Celli, Jiechen Zhang, Jeanmarie R. Gonzalez, Jason M. Meyer, Brook Abegaze, Merisa Piper, Peter M. Elias, Katrina Abuabara, Carl Grünfeld, Mao‐Qiang Man, Tiffany C. Scharschmidt, Theodora M. Mauro · 发表于：Journal of Investigative Dermatology · 年份：2024 · DOI：10.1016/j.jid.2024.12.010 · 被引用次数：3 · 研究领域：Dermatology and Skin Diseases、Contact Dermatitis and Allergies、Psoriasis: Treatment and Pathogenesis

The skin is a major contributor to the age-associated rise in systemic inflammation, known as “inflammaging” (Yang et al, 2023; Ye et al, 2019). Previous research from our laboratory has shown that restoring epidermal barrier function in older mice, through application of a topical emollient, can normalize serum cytokine levels to those seen in young age (Hu et al, 2017; Man et al, 2015). This not only demonstrates that the skin is a major source of age-related systemic inflammation but also serves as proof of concept that this inflammation is amenable to treatment.