Differential impact of TyG and TyG-BMI indices on short- and long-term mortality in critically ill ischemic stroke patients

作者：Yuehua Pu, Na Xing, Ying Wang, Huan Wang, Xu Jiang, Xuejing Li · 发表于：BMC Cardiovascular Disorders · 年份：2024 · DOI：10.1186/s12872-024-04450-5 · 被引用次数：21 · 研究领域：Acute Ischemic Stroke Management、Nutrition and Health in Aging、Hyperglycemia and glycemic control in critically ill and hospitalized patients

BACKGROUND: Ischemic stroke is a major contributor to global morbidity and mortality, particularly in critically ill patients in intensive care units (ICUs). While advances in stroke management have improved outcomes, predicting mortality remains challenging due to the involvement of complex metabolic and cardiovascular factors. The triglyceride-glucose (TyG) index, a marker for insulin resistance, has gained attention for its potential to predict adverse outcomes in stroke patients. Furthermore, the TyG-BMI index, which combines TyG with body mass index (BMI), may offer a more comprehensive measure by accounting for obesity-related metabolic burden. However, the comparative impact of these indices on short- and long-term mortality among critically ill ischemic stroke patients remains unclear. METHODS: This retrospective cohort study analyzed data from the Medical Information Mart for Intensive Care IV (MIMIC-IV 3.0) database, including 1,334 critically ill ischemic stroke patients. The patients were divided into four groups based on TyG and TyG-BMI quartiles, respectively. Cox proportional hazards models were employed to assess the association of these indices with 30-day, 90-day, 180-day, and 1-year all-cause mortality (ACM). Kaplan-Meier survival analysis was used to compare survival rates across different index levels. We utilized restricted cubic splines (RCS) to examine the association between the TyG, TyG-BMI index and the specified outcomes. Furthermore, TyG and TyG-B...