Comparison of Remimazolam-Flumazenil and Propofol on Psychomotor Function and Emergence Following General Anesthesia in Surgical Abortion: A Randomized Controlled Trial

作者：J. Gu, Yang Liu, Xiaoyan Lin, Lei Fu, Jianbo Liu, Bona Sun, Xiaoyu Li, Bo Lu · 发表于：Drug Design Development and Therapy · 年份：2024 · DOI：10.2147/dddt.s486892 · 被引用次数：11 · 研究领域：Anesthesia and Sedative Agents、Anesthesia and Pain Management、Intraoperative Neuromonitoring and Anesthetic Effects

Objective: This study aims to compare the recovery profiles of remimazolam combined with flumazenil against those of propofol in patients undergoing painless surgical abortion, focusing on psychomotor function and emergence. Rapid recovery and restoration of psychomotor function are critical for enhancing patient safety and satisfaction in outpatient procedures like surgical abortion. Methods: A total of 110 patients scheduled for surgical abortion were randomly assigned to either the remimazolam group (Group R) or the propofol group (Group P) in a 1:1 ratio. Both groups received intravenous sufentanil for induction, followed by either remimazolam or propofol. Psychomotor function was assessed using the Digit Symbol Substitution Test (DSST) and Trieger Dot Test (TDT) at 30, 60, and 90 minutes post-anesthesia. Emergence parameters, including time to first eye opening and first verbal response, were recorded. Adverse events and hemodynamic parameters were also monitored. Results: The DSST scores at 30, 60, and 90 minutes post-anesthesia were similar between the Remimazolam group and the Propofol group ( F =50.61, P > 0.05, η ²=0.0051). The TDT results were also comparable between the groups at all time points ( F =0.12, 0.11 and 0.30, all P > 0.05, η² =0.0002, 0.0003 and 0.0008). At 30 or 60 minutes post-anesthesia, DSST scores or TDT performance were significantly worse compared to preoperative baseline in both groups, indicating reduced psychomotor function ( P < 0.05). The R...