Expert consensus and current landscape of NUT carcinoma: A comprehensive strategy from diagnosis to treatment

作者：Zhuomiao Ye, Xin Li, Fei Xie, Chao Deng, Dan Yang, Hongle Li, Yuanzhi Lü, Zhenbin Mao, Qingwei Meng, Lidong Wang, Zhe Wang, Jinliang Xing, Chong Bai, Zhimin Bian, Paolo Boffano, Steven T. Brower, Rui Chen, Wantao Chen, Jinhai Deng, Xinpei Deng, Chunming Ding, Jianchun Duan, Song Duan, Nejat Düzgüneş, Pierfrancesco Franco, Guobin Fu, Lichao Guo, Ye Guo, Ruiqin Han, Ling Hao, Lang He, Yayi He, Xiaotong Hu, Junmei Jia, Yanfang Jiang, Weilin Jin, Kalevi Kairemo, Mohamed Kamal, Evan T. Keller, Rensheng Lai, Chao Li, Jun Li, Lifeng Li, Qingxia Li, Wenbin Li, Xuening Li, Yang Li, Yongsheng Li, Yu Li, Mikael S. Lindström, Xiaodong Liu, Yan Liu, Yanqing Liu, Zengjun Liu, José Manuel Lopes, Hongyang Lu, Xiangwen Luo, Wenping Ma, Hongxue Meng, Anjie Min, Amancio Carnero Moya, Athanasios G. Papavassiliou, Xifeng Pan, Min Peng, Helmut Popper, Lixin Qiu, Di Qu, Axel H. Schönthal, Vishal G. Shelat, Yi Shi, Аlexander А. Shtil, Hifzur R. Siddique, Yang Song, H.Q. Su, Min Tang, Mengyuan Wang, Qiming Wang, Shubin Wang, Bing Wei, Dawei Wu, Longxiang Wu, Lijun Xu, Yubo Yan, Nong Yang, Zihuan Yang, Zhi Yi, Songtao Yu, Heng Zhang, Hongmei Zhang, Lijuan Zhang, Jianfu Zhao, Zheng Zhao, Shaoquan Zheng, Chengzhi Zhou, Pu Zhou, Qin Zhou, Guodong Zhu, Yan Qin, Minghui Zhang, Mingzhu Yin · 发表于：Tumor Discovery · 年份：2024 · DOI：10.36922/td.4904 · 被引用次数：6 · 研究领域：Protein Degradation and Inhibitors、Ubiquitin and proteasome pathways、PI3K/AKT/mTOR signaling in cancer

Nuclear protein of the testis (NUT) carcinoma is a rare and highly aggressive malignancy characterized by the rearrangement of the NUT midline carcinoma family member 1 (NUTM1) gene. Nevertheless, standardized strategies for its diagnosis and treatment remain unavailable, underscoring the need for expert consensus. To address this gap, we conducted a systematic review to gather comprehensive information on NUT carcinoma from five databases: PubMed, Web of Science, Embase, Cochrane Library, and Ovid Medline. This expert consensus was collaboratively developed by a team of international multidisciplinary experts, in partnership with the NUT Carcinoma Diagnosis Working Group of the Chinese Anti-Cancer Association’s Oncogene Diagnosis Professional Committee. This working group comprises medical oncologists, radiation oncologists, surgical oncologists, pathologists, nurses, molecular biologists, statisticians, and bioinformatics specialists. A systematic review, based on data from 526 patients across 199 articles, was conducted to comprehensively explore various characteristics, including demographic features (e.g., patient gender, distribution regions, and age), tumor-node-metastasis (TNM) classification stage, clinical symptoms, tumor size, metastatic patterns, immunohistochemical (IHC) findings, treatment modalities, prognosis-related information, and NUTM1 fusion partners. We have developed an expert consensus on diagnosing and treating NUT carcinoma using a multidis...