[Research progress in anti-enzymatic antimicrobial peptides].

作者：Changxuan Shao, Mengcheng Wang, Yuanmengxue Wang, Shiqi He, Yongjie Zhu, Anshan Shan · 发表于：PubMed · 年份：2024 · DOI：10.13345/j.cjb.240077 · 被引用次数：1 · 研究领域：Antimicrobial Peptides and Activities、Probiotics and Fermented Foods、Protein Hydrolysis and Bioactive Peptides

Antimicrobial peptides (AMPs) are small molecular peptides widely existing in the innate immunity of organisms, serving as the first line of defense. Natural AMPs possess various biological activities and are difficult to develop drug resistance. However, they are easily broken down by digestive enzymes in the body. In recent years, increasing methods have been reported to enhance the stability of AMPs, including incorporation of unnatural amino acids, chemical modifications, strategic avoidance of enzyme cleavage sites, cyclization, and nano peptide design. This review summarizes the methods for improving the stability of AMPs against protease degradation, aiming to provide references for further research in this field.