Luteolin Exhibits Anxiolytic and Antidepressant Potential in Parkinson’s Disease Rat: Antioxidant and Anti-Inflammatory Effects

作者：Ruifang She, Zhaoting Zhang, Miaomiao Han, Dapeng Zhao, Xiangting Li, Xiangting Li, Jian Zhou, Xinping Zhang, Xinping Zhang, Xiaohong Li, Xiaohong Li · 发表于：Rejuvenation Research · 年份：2024 · DOI：10.1089/rej.2024.0045 · 被引用次数：17 · 研究领域：Parkinson's Disease Mechanisms and Treatments、Neuroinflammation and Neurodegeneration Mechanisms、Alzheimer's disease research and treatments

Parkinson's disease (PD) is accompanied by a complex array of nonmotor and motor manifestations. The exploration of anti-inflammatory and antioxidant active ingredient as potential therapeutic interventions in PD-associated mood alterations has gained significant attention. This study aimed to assess the antidepressant and anxiolytic properties of luteolin (LTN), a potent antioxidant and anti-inflammatory component, using a 6-hydroxydopamine (6-OHDA)-induced animal model of PD. Rats were administered LTN (10, 25, and 50 mg/kg, per oral) and fluoxetine (10 mg/kg/per oral) over a 28-day period. Behavioral tests were employed to estimate the depression- and anxiety-like behaviors. Rats treated with LTN exhibited significant improvement in 6-OHDA-induced mood alterations, as per behavioral tests. Additionally, LTN treatment led to increased hippocampal levels of catalase and superoxide dismutase, and a reduction in malondialdehyde. LTN downregulated the gene expression of nuclear factor kappa B (NF-κB)/nod-like receptor (NLR) pyrin domain-containing 3 (NLRP3) axis components, including NF-κB, NLRP3, ASC, and Caspase1 and reduced the protein level of pro-inflammatory cytokines, including interleukin (IL)-6, interleukin (IL)-1β, and tumor necrosis factor alpha (TNF-α), in addition to augmenting the protein levels of TNF-α, IL-1β, and IL-6. Furthermore, LTN exhibited an upregulatory effect on the anti-inflammatory cytokine IL-10 within the hippocampus of 6-OHDA-induced PD rats. Also...