Application of Spatial Transcriptomics in Digestive System Tumors

作者：Bowen Huang, Yingjia Chen, Shuqiang Yuan · 发表于：Biomolecules · 年份：2024 · DOI：10.3390/biom15010021 · 被引用次数：6 · 研究领域：Single-cell and spatial transcriptomics、Cancer Genomics and Diagnostics、Immune cells in cancer

In the field of digestive system tumor research, spatial transcriptomics technologies are used to delve into the spatial structure and the spatial heterogeneity of tumors and to analyze the tumor microenvironment (TME) and the inter-cellular interactions within it by revealing gene expression in tumors. These technologies are also instrumental in the diagnosis, prognosis, and treatment of digestive system tumors. This review provides a concise introduction to spatial transcriptomics and summarizes recent advances, application prospects, and technical challenges of these technologies in digestive system tumor research. This review also discusses the importance of combining spatial transcriptomics with single-cell RNA sequencing (scRNA-seq), artificial intelligence, and machine learning in digestive system cancer research.