Advancements in omics technologies: Molecular mechanisms of acute lung injury and acute respiratory distress syndrome (Review)

作者：Zhihuan Zheng, Xinyu Qiao, Junhao Yin, Junjie Kong, Wanqing Han, Jing Qin, Fanda Meng, Ge Tian, Xiujing Feng · 发表于：International Journal of Molecular Medicine · 年份：2024 · DOI：10.3892/ijmm.2024.5479 · 被引用次数：17 · 研究领域：Metabolomics and Mass Spectrometry Studies、thermodynamics and calorimetric analyses、Respiratory Support and Mechanisms

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is an inflammatory response arising from lung and systemic injury with diverse causes and associated with high rates of morbidity and mortality. To date, no fully effective pharmacological therapies have been established and the relevant underlying mechanisms warrant elucidation, which may be facilitated by multi‑omics technology. The present review summarizes the application of multi‑omics technology in identifying novel diagnostic markers and therapeutic strategies of ALI/ARDS as well as its pathogenesis.