Night shift work and prostate cancer: a large cohort study from UK Biobank and Mendelian randomisation study

作者：Guorong Yang, Yingzi Yang, Kaikai Lv, Yangyang Wu, Tao Song, Qing Yuan · 发表于：BMJ Open · 年份：2024 · DOI：10.1136/bmjopen-2024-084401 · 被引用次数：3 · 研究领域：Circadian rhythm and melatonin、Sleep and Work-Related Fatigue、Dietary Effects on Health

OBJECTIVE: The global concern regarding the health implications of night shift work has escalated. Nevertheless, variations exist in the observed association between night shift work and prostate cancer (PCa). This study aims to systematically explore the association between night shift work and the risk of PCa. DESIGN: Cohort study and Mendelian randomisation (MR) study were used. SETTING: Cohort study data was from the UK Biobank (UKB). MR study using data was from the Finngen study and UKB through the Integrative Epidemiology Unit (IEU) Open Genome-Wide Association Study Project. PARTICIPANTS: Participants without prior PCa in paid employment or self-employment were include in the current work schedule cohort, participants without PCa who provided employment history formed the lifetime night shift work cohort. MAIN OUTCOME MEASURES: The outcome, incident PCa, was obtained from cancer register through linkage to national cancer databases. National cancer registries centralised information received from separate regional cancer centres around the UK. RESULTS: A total of 130 853 participants were included in the current work schedule cohort, while the lifetime night shift work cohort comprised 49 511 participants. Over a median follow-up duration of 13.9 years, the current work schedule cohort witnessed 4993 incident cases of PCa, while the lifetime night shift work cohort recorded 2022 PCa cases. In the analysis of the current work schedule, final model showed that no signif...