Ultra-Widefield Optical Coherence Tomography Beyond the Ora Serrata in Retinopathy of Prematurity

作者：Elizabeth V. Roti, Shuibin Ni, Yakub A. Bayhaqi, Susan Ostmo, Spencer S. Burt, Mani K. Woodward, John D. Jackson, Aaron S. Coyner, Michael F. Chiang, David Huang, J. Peter Campbell, Yifan Jian, Benjamin K. Young · 发表于：JAMA Ophthalmology · 年份：2024 · DOI：10.1001/jamaophthalmol.2024.5533 · 被引用次数：10 · 研究领域：Retinopathy of Prematurity Studies、Ophthalmology and Visual Impairment Studies、Child Abuse and Related Trauma

Importance: Capturing high-quality images of the entire peripheral retina while minimizing the use of scleral depression could increase the quality of examinations for retinopathy of prematurity (ROP) while reducing neonatal stress. Objective: To evaluate whether an investigational handheld ultra-widefield optical coherence tomography (UWF-OCT) device without scleral depression can be used to document high-quality images of the peripheral retina for use in ROP examinations. Design, Setting, and Participants: This was a prospective, cross-sectional study in the neonatal intensive care unit at a single academic medical center. Study participants were neonates in the neonatal intensive care unit who met standard ROP screening criteria (birth weight ≤1500 g; gestational age ≤30 weeks). Examinations were performed from January 2, 2023, to May 12, 2024. Data analysis was performed in July 2024. Exposure: An investigational, contact-based, 800-kHz, 140° (visual angle) UWF-OCT field-of-view handheld device was used during regular ROP examinations. Main Outcomes and Measures: Images from each examination were captured using the UWF-OCT device, and the zone, stage, and presence of plus disease were diagnosed. If the UWF-OCT system was unable to capture diagnosis, this was recorded. Results: A total of 507 examinations were performed on 83 neonates (mean [SD] birth weight, 905.1 [362.5] g; mean [SD] gestational age, 189.5 [19.1] days) with this system. The vascular border and disease wa...