Effects of exercise on bone mass and bone metabolism in adolescents: a systematic review and meta-analysis

作者：Wen‐Hua Zhang, Xiaoqiang Wang, Yurong Liu, Qiang He, Qixin Ding, Jingqi Mei, Xun� Li · 发表于：Frontiers in Physiology · 年份：2024 · DOI：10.3389/fphys.2024.1512822 · 被引用次数：20 · 研究领域：Bone health and osteoporosis research、Alkaline Phosphatase Research Studies、Vitamin K Research Studies

Objective Meta-analysis was used to evaluate the effects of an exercise intervention on bone mineral content (BMC), bone mineral density (BMD), and bone metabolism in adolescents. Methods A systematic search of PubMed, Embase, Cochrane Library, and Web of Science for RCTs on “exercise, adolescents, BMD, bone metabolism” up to 10 September 2024. Included RCTs focused on effects of exercise on BMC, BMD, and bone metabolism in 10–19 years old, with physical activity as exercise group and daily living/primal exercise as control group. Outcome metrics included lumbar spine, femoral neck, whole body BMC and BMD, bone alkaline phosphatase (BALP), procollagen type 1N-terminal propeptide (PINP), osteocalcin (OC), and type I collagen carboxy-terminal peptide (CTX). Exclusion criteria included duplicates, non-RCTs, non-adolescent studies, and non-compliance with indicators. Meta-analyses were performed using RevMan 5.4, and quality assessed by Cochrane’s tool. Effect sizes were estimated using standardized mean differences ( SMDs ) and 95% confidence intervals ( CIs ), and heterogeneity was assessed using the I 2 statistic to determine fixed or random effects models. Results Fifteen articles with a total of 723 subjects were included. The meta-analysis showed that, compared to the control group, (i) exercise was effective in increasing adolescents’ overall BMC ( SMD = 0.16, 95% CI : 0.06–0.27, p = 0.003) and BMD ( SMD = 0.26, 95% CI : 0.13–0.40, p = 0.0001). (ii) Subgroup analyses showe...