Disrupting heroin-associated memory reconsolidation through actin polymerization inhibition in the nucleus accumbens core

作者：Haiting Zhao, Haoyu Li, Meng Li, Peng Du, Xin Mo, Mengqi Gong, Jiaxin Chen, Yiwei Liao · 发表于：The International Journal of Neuropsychopharmacology · 年份：2024 · DOI：10.1093/ijnp/pyae065 · 被引用次数：1 · 研究领域：Memory and Neural Mechanisms、Neurotransmitter Receptor Influence on Behavior、Neuroscience and Neuropharmacology Research

BACKGROUND: Understanding drug addiction as a disorder of maladaptive learning, where drug-associated or environmental cues trigger drug cravings and seeking, is crucial for developing effective treatments. Actin polymerization, a biochemical process, plays a crucial role in drug-related memory formation, particularly evident in conditioned place preference paradigms involving drugs like morphine and methamphetamine. However, the role of actin polymerization in the reconsolidation of heroin-associated memories remains understudied. METHODS: This study employed a rodent model of self-administered heroin to investigate the involvement of actin polymerization in the reconsolidation of heroin-associated memories. Rats underwent ten days of intravenous heroin self-administration paired with conditioned cues. Subsequently, a 10-day extinction phase aimed to reduce heroin-seeking behaviors. Following this, rats participated in a 15-minute retrieval trial with or without cues. Immediately post-retrieval, rats received bilateral injections of the actin polymerization inhibitor Latrunculin A (Lat A) into the nucleus accumbens core (NACc), a critical brain region for memory reconsolidation. RESULTS: Immediate administration of Lat A into the NACc post-retrieval significantly reduced cue-induced and heroin-primed reinstatement of heroin-seeking behavior for at least 28 days. However, administering Lat A 6-hour post-retrieval or without a retrieval trial, as well as administering Jasplaki...