Advances and applications of dynamic surface-enhanced Raman spectroscopy (SERS) for single molecule studies

作者：Yanqiu Zou, Huaizhou Jin, Qifei Ma, Zhenrong Zheng, Shukun Weng, Karol Kołątaj, Guillermo P. Acuna, Ilko Bald, Denis Garoli · 发表于：Nanoscale · 年份：2024 · DOI：10.1039/d4nr04239e · 被引用次数：31 · 研究领域：Spectroscopy Techniques in Biomedical and Chemical Research、Gold and Silver Nanoparticles Synthesis and Applications、Electrochemical Analysis and Applications

Dynamic surface-enhanced Raman spectroscopy (SERS) is nowadays one of the most interesting applications of SERS, in particular for single molecule studies. In fact, it enables the study of real-time processes at the molecular level. This review summarizes the latest developments in dynamic SERS techniques and their applications, focusing on new instrumentation, data analysis methods, temporal resolution and sensitivity improvements, and novel substrates. We highlight the progress and applications of single-molecule dynamic SERS in monitoring chemical reactions, catalysis, biomolecular interactions, conformational dynamics, and real-time sensing and detection. We aim to provide a comprehensive review on its advancements, applications as well as its current challenges and development frontiers.