Enantioselective Synthesis of Isoindolinone by Sequential Palladium-Catalyzed Aza-Heck/Suzuki Coupling Reaction

作者：Lei Wang, Wenyu Zhang, Shuaijie Wu, Qing Wu, Ying Han, Chao‐Guo Yan, Guodong Zhang · 发表于：Organic Letters · 年份：2024 · DOI：10.1021/acs.orglett.4c04239 · 被引用次数：10 · 研究领域：Synthesis and pharmacology of benzodiazepine derivatives、Cancer Treatment and Pharmacology、Synthetic Organic Chemistry Methods

-phenyl hydroxamic ethers with readily available arylboronic and alkenyl boronic acids. This protocol is enabled by a palladium catalyst paired with chiral phosphoramidite ligands, particularly under mild reaction conditions, yielding efficient and succinct synthetic routes to chiral isoindolinones with high enantioselectivity. Furthermore, this reaction exhibits excellent functional group compatibility and a rich diversity of subsequent transformations.