68Ga-pentixafor PET/CT Is a Supplementary Method for Primary Aldosteronism Subtyping Compared with Adrenal Vein Sampling

作者：Tieci Yi, Difei Lu, Yonggang Cui, Zheng Zhang, Xing Yang, Jianhua Zhang, Lin Qiu, Haoyu Weng, Lin Liu, Xiaojiang Duan, Guangyu Zhao, Wei Ma, Ying Gao, Yan Fan · 发表于：Molecular Imaging and Biology · 年份：2024 · DOI：10.1007/s11307-024-01976-0 · 被引用次数：14 · 研究领域：Hormonal Regulation and Hypertension、Adrenal and Paraganglionic Tumors、Adrenal Hormones and Disorders

Abstract Purpose To investigate the diagnostic efficacy of 68 Ga-pentixafor positron emission tomography/computed tomography (PET/CT) in primary aldosteronism (PA) subtyping and lateralization of aldosterone secretion in PA patients. Procedures 37 patients who were diagnosed with PA, were prospectively enrolled in the study, and underwent adrenal vein sampling (AVS) after 68 Ga-pentixafor PET/CT was conducted. Lateralization index (LI), defined as aldosterone/cortisol ratio in the dominant side to the contralateral adrenal vein when bilateral adrenal vein catheterization succeeded, and the aldosterone/cortisol ratio in the left adrenal vein to IVC (LAV/IVC) when the catheterization of right adrenal vein failed, were applied to determine lateralization side. Statistical analysis was performed using SPSS 21.0. Results The female proportion of all patients with PA was 32.4% (12/37), and the mean age was 51.3 ± 10.9 years. Patients with bilateral adrenal mass accounted for 54.1% (20/37), and 10 of them (27.0%) had adrenal hyperplasia or adrenal nodules ≤ 1.0 cm. In all 37 patients, the sensitivity, specificity and accuracy of 68 Ga-pentixafor PET/CT in distinguishing lateralization by visualization were 89.3%, 77.8% and 86.5%, respectively. The area under the ROC curve for detecting positive lateralization based on the value of 68 Ga-pentixafor SUV max was 0.750 (95%CI 0.578–0.922, p = 0.026). The optimum SUV max cut-off value was 6.86, with the sensitivity of 78.6%, specificity ...