A correlation study between blood glucose fluctuation and chronic pain in the older people with type 2 diabetes mellitus

作者：Qinyi Huang, Mengjie Cui, Yangliu Yin, Cancan Hui, Yuwei Cheng, Shuqian Wang, Xiujuan Hu, Xiaorong Yin, Xiaoxiang Zhang, Xinyu Sun, Tiantian Tang, Lang Lang, Yan Sun · 发表于：BMC Geriatrics · 年份：2024 · DOI：10.1186/s12877-024-05616-8 · 被引用次数：5 · 研究领域：Hyperglycemia and glycemic control in critically ill and hospitalized patients、Diabetes Management and Research、Pain Mechanisms and Treatments

OBJECTIVES: To investigate the correlation between blood glucose fluctuation parameters and other clinical data with chronic pain in older patients ( ≧ 60 years) with type 2 diabetes mellitus (T2DM), as well as evaluating the predictive value of risk of these parameters for chronic pain. METHODS: Clinical data were collected from 60 older patients with T2DM undergoing chronic pain who were hospitalized in the Department of Geriatric Endocrinology at the First Affiliated Hospital of Anhui Medical University. Pain scores using the numeric rating scale (NRS) were administered to all study participants by a dedicated person. Based on their pain scores, patients were categorized into two groups: mild pain group (NRS ≤ 5, n = 28) and severe pain group (NRS > 5, n = 32). Blood glucose levels were continuously monitored using the Continuous Glucose Monitoring System (CGMS). Spearman correlation analysis was performed to investigate the correlation between pain scores and blood glucose fluctuation parameters, as well as other clinical data of concern. Comparing general clinical information and relevant data recorded by CGMS between the two groups. Binary logistic regression was used to identify factors influencing the severity of chronic pain in old patients with T2DM combined with chronic pain. Additionally, the predictive value of Mean Amplitude of Glycemic Excursions (MAGE), Coefficient of Variation (CV), and Time in Range (TIR) for chronic pain severity was assessed using Receiver...