Global Burden of Early-Onset Ischemic Heart Disease, 1990 to 2019

作者：Xiao Liu, Xiao Liu, Yuting Wu, Yuting Wu, Fei Li, Xin‐Rui Qi, Liyan Niu, Yifan Wu, Yifan Wu, Jitao Ling, Wengen Zhu, Qingqing Li, Xinyu Liu, Xinyu Liu, Jing Zhang, Yunfeng Shen, Zhiwei Yan, Deju Zhang, Jingfeng Wang, Yuling Zhang, Peng Yu · 发表于：JACC Advances · 年份：2024 · DOI：10.1016/j.jacadv.2024.101466 · 被引用次数：8 · 研究领域：Acute Myocardial Infarction Research、Cardiovascular Health and Risk Factors、Birth, Development, and Health

Background: Early-onset ischemic heart disease (IHD) is a growing burden associated with high disability and death. Objectives: This study aimed to estimate the burden of incidence, prevalence, and disability-adjusted life years (DALY) of early-onset IHD from 1990 to 2019. Methods: Data on the burden of early-onset IHD (men<55 years, women<65 years), including prevalence, incidence, DALY, and deaths, were collected from the Global Burden of Disease study for 204 countries and territories from 1990 to 2019. Results: In 2019, early-onset IHD affected 5.34 million (95% uncertainty interval [UI]: 3.96-6.96) individuals globally. This resulted in 58.48 million (95% UI: 52.65-64.69) DALY and 1.44 million (95% UI: 1.29-1.59) deaths. Countries with a middle sociodemographic index (SDI) had the highest incidence cases (1.79 million, 95% UI: 1.32-2.34) and the low-middle SDI countries had the highest age-standardized incidence rate of 179.34 per 100,000 (95% UI: 134.38-231.94). Low-middle SDI countries exhibited the highest age-standardized death rate (57.13 per 100,000, 95% UI: 48.45-66.53) and age-standardized DALY rate (2,309.67 per 100,000, 95% UI: 1962.31-2,693.93). Globally, female incidence cases (2.77 million, 95% UI: 2.04-3.64) surpassed male (2.57 million, 95% UI: 1.92-3.32). The top 2 attributable risk factors were high low-density lipoprotein cholesterol and high systolic blood pressure. Conclusions: The global incidence rate of early-onset IHD decreased from 1990 to 2019. ...