Recent advancements in visible-light-induced direct C(3)–H functionalization of quinoxalin-2(1H)-ones

作者：Xin Han, Yifan Guo, Yifan Guo, Y. Hu, Yuanyuan Chang, Yujing Guo, Yujing Guo, Linlin Shi · 发表于：Green Synthesis and Catalysis · 年份：2024 · DOI：10.1016/j.gresc.2024.12.003 · 被引用次数：7 · 研究领域：Synthesis and Biological Evaluation、Radical Photochemical Reactions、Fluorine in Organic Chemistry

Quinoxalin-2(1 H )-ones are unique nitrogen-containing organic compounds with wide applications in the agrochemical, pharmaceutical, and chemical industries as well as in material science. During the last decades, visible-light-promoted photoredox catalysis has emerged as a versatile platform for constructing quinoxalin-2(1 H )-one scaffolds under exceptionally mild conditions. In this review, we provide an overview of recent advances in photocatalytic direct C(3)–H functionalization of quinoxaline-2(1 H )-ones, including the construction of C(3)–C bonds and C(3)–R F /C/O/N/Cl/S/D bonds, as well as the related reaction mechanisms. We aim to enhance the methods for the reaction of quinoxalin-2(1 H )-ones at the C-3 position, which have extensive applications in organic synthesis and medicinal chemistry. In this review, we provide an overview of recent advances in photocatalytic direct C(3)–H functionalization of quinoxaline-2(1 H )-ones, including the construction of C–C bonds and C–R F /C/O/N/Cl/S/D bonds, as well as the related reaction mechanisms. We aim to enhance the methods for the reaction of quinoxalin-2(1 H )-ones at the C-3 position, which have extensive applications in organic synthesis and medicinal chemistry.