Risk factors associated with pregnancy outcomes in patients with recurrent pregnancy loss after treatment

作者：Tingfeng Fang, Xiaohui Ji, Zhen Su, Ao Zhang, Liqiong Zhu, Jing Tang, Zhuoyao Mai, Haiyan Lin, Nengyong Ouyang, Hui Chen · 发表于：BMC Pregnancy and Childbirth · 年份：2024 · DOI：10.1186/s12884-024-07048-z · 被引用次数：6 · 研究领域：Reproductive System and Pregnancy、Pregnancy and Medication Impact、Organ and Tissue Transplantation Research

BACKGROUND: The treatment for recurrent pregnancy loss (RPL) has been addressed in international guidelines. However, limited studies have investigated the risk factors associated with pregnancy and live birth outcomes in patients with RPL after treatment. The objective of this study was to offer a comprehensive assessment of the risk factors for pregnancy loss in patients with a history of RPL following therapeutic interventions. METHODS: This retrospective cohort study involved 431 women in early pregnancy with a history of RPL who experienced treatment at the Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, between June 2018 and June 2020. The main outcome measures were the ongoing pregnancy ≥ 12 weeks and the live birth outcomes. Univariate and multivariate logistic regression analyses were conducted to identify the risk factors for pregnancy loss < 12 weeks and live birth outcomes. RESULTS: Patient's age and the prevalence of uterine malformations were significantly different between the patients with and without ongoing pregnancy ≥ 12 weeks (32.64 ± 5.08 vs. 31.54 ± 4.34, P = 0.026; 34.70% vs. 24.60%, P = 0.035). The risk of pregnancy loss < 12 weeks was significantly increased with age and those with uterine abnormalities (adjusted OR: 1.48 [95% CI: 1.05 to 2.07], P = 0.025; adjusted OR:1.78 [95% CI 1.11 to 2.79], P = 0.016). The risk of non-live birth was significantly increased in couples with parental karyotype abnormal...