Cardiac deceleration capacity and acceleration capacity have diagnostic value in patients with vasovagal syncope regardless of age

作者：Jijing Wang, Jinyi Xu, Yanyan Qiu, Ruike Yang, Wentao Wang, Chuanyu Gao · 发表于：Frontiers in Cardiovascular Medicine · 年份：2024 · DOI：10.3389/fcvm.2024.1495129 · 被引用次数：5 · 研究领域：Cardiovascular Syncope and Autonomic Disorders、Heart Rate Variability and Autonomic Control、Heart rate and cardiovascular health

Background Deceleration capacity (DC) and acceleration capacity (AC) are used to characterize autonomic regulation. The purpose of this study was to evaluate the autonomic nervous function in patients with vasovagal syncope (VVS) and to evaluate the diagnostic value of DC and AC for VVS. Methods A total of 94 consecutive patients with VVS [51.0 (38.0–60.0) years; 48 males] and 76 healthy subjects [53.0 (44.3–62.8) years; 46 males] were recruited as controls. The study compared DC, AC, and heart rate variability (HRV) in 24-h ECG, echocardiogram, and biochemical examinations between the two groups. Results DC was significantly higher (9.3 ± 2.1 vs. 7.4 ± 1.4 ms, p &lt; .001) and AC was lower (−9.3 ± 2.1 vs. −7.3 ± 1.3 ms, p &lt; .001) in the syncope group compared to the control group. HRV indicators were higher in the syncope group. In multivariable analyses, DC [odds ratio = 1.746 (95% CI, 1.389–2.195); p &lt; .001], AC [odds ratio = 0.553 (95% CI, 0.435–0.702); p &lt; .001] were independently associated with syncope. Mean HR was associated with syncope only in patients &lt;60 years of age. Receiver operating characteristics (ROC) curves showed areas under curve (AUC) of DC/AC for predicting syncope are 0.755/0.765 with sensitivity of 56.4%/60.6% and specificity of 93.4%/88.2%. Conclusion Patients with VVS exhibit higher DC and lower AC. Both DC and AC are independently correlated with syncope. A DC value &gt;9.0 ms and an AC value −9.0 ms could poten...