Centering autonomy and choice to support oral PrEP utilization among people who inject drugs: qualitative lessons from HPTN 094 INTEGRA

作者：Amaya Gabriela Perez-Brumer, Rose A. Schmidt, Rebecca Kennedy, Jordan E. Lake, Yolanda R. Villarreal, Sydney Bornstein, Irene C. Kuo, Omar Nieto, Julie C. Franks, Cécile Denis, Nabila El–Bassel, STEVEN J. SHOPTAW, Peter J. Davidson, Laramie R. Smith · 发表于：Addiction Science & Clinical Practice · 年份：2024 · DOI：10.1186/s13722-024-00520-3 · 被引用次数：5 · 研究领域：HIV, Drug Use, Sexual Risk、HIV/AIDS Research and Interventions、Sex work and related issues

BACKGROUND: Oral Pre-exposure prophylaxis (PrEP) is effective in preventing HIV transmission. However, despite high rates of HIV risk behaviors among people who inject drugs (PWID), this population remains underserved by current HIV prevention efforts in the United States. To address this challenge, we conducted an in-depth exploration of perspectives on using oral PrEP among PWID engaged in the HIV Prevention Trials Network (HPTN) 094 INTEGRA Study. METHODS: Guided by the Practical, Robust, Implementation, and Sustainability Model (PRISM), our qualitative study drew on semi-structured interviews conducted as part of the embedded implementation science evaluation of HPTN 094 INTEGRA. Seventy-seven PWID participants from five sites across New York City, Houston, Los Angeles, Philadelphia, and Washington DC were interviewed to assess intervention delivery, care access, and engagement sustainability. Audio files were transcribed verbatim and analyzed via an inductive and deductive thematic approach. RESULTS: Most participants (n = 46, 59.7%) discussed oral PrEP during their interview, though not directly prompted. Participants discussing PrEP had a mean age of 41.6 years and were predominantly white (54.3%) and cisgender men (60.9%). Among these, 15 participants described using PrEP. All participants had facilitated access to oral PrEP. Yet, the choice to use PrEP was influenced by personal risk perceptions, (mis)information about PrEP, and external factors (i.e. housing, financ...