Continuous renal replacement therapy with adsorbing filter oXiris in the treatment of sepsis associated acute kidney injury: a single-center retrospective observational study

作者：Feng Zheng, Yi-lan Wang, Weiyi Zhou, Jing Zhang, Min Lü, Nifang Pan, Jian He, Qian Zhang, Lan Cao, Jia-Ching Wu, Yan Gu, Lihua Qiu, Hong-wei Ye · 发表于：BMC Nephrology · 年份：2024 · DOI：10.1186/s12882-024-03897-0 · 被引用次数：14 · 研究领域：Acute Kidney Injury Research、Ultrasound in Clinical Applications、Sepsis Diagnosis and Treatment

BACKGROUND AND OBJECTIVE: Critical bedside ultrasound is widely used in clinical practice, and it can monitor renal perfusion. The reduction of renal perfusion and inflammatory injury are two contributing factors to sepsis-associated acute kidney injury (SA-AKI).The aim of this study was to examine whether the oXiris filter was useful in the continuous renal replacement therapy(CRRT) treatment of SA-AKI patients. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: We performed a retrospective single-center observational study and enrolled two hundred and forty-three SA-AKI patients from January 2022 to December 2023, who were divided into the oXiris group (n = 88) and the control group (n = 155). The primary endpoints were the 28-day recovery of renal function and 28-day all-cause mortality. The secondary endpoints included renal Doppler markers (RRI, RVSI, and PDU), SOFA, vasoactive-inotropic score (VIS), inflammatory markers (PCT, CRP, IL-10 and TNFα), lactate level, and length of stay in ICU and hospital. RESULTS: For the primary endpoint, the rates of complete recovery, partial recovery, and dialysis dependence were observed to be 60.3%, 13.6%, and 26.1% in the oXiris group, respectively, compared to 63.9%, 15.5%, and 20.6% in the control group. The 28-day all-cause mortality was not different in the two groups (22.7% vs. 27.1%). For the secondary endpoint, the oXiris group exhibited greater reductions in VIS scores compared to the control group within the first 24 h (p = 0....