Expert consensus on a multidisciplinary approach for the management of multiple myeloma-related bone disease

作者：Yutong Wang, Qiming Xu, Yuan Li, Yongbin Su, Ling Wang, Xiaoquan Wang, Jian Ge, Hongmei Jing, Yuxing Guo, Yalin Chen, Xianan Li, Junling Zhuang, Jing Tan, Xiaobo Wang, Li-Ye Zhong, Jun Luo, Peng Zhao, Shengjin Fan, Jinhai Ren, Haiping Yang, Heng Mei, Chunyan Sun, Chunrui Li, Xuemei Sun, Xuechun Lu, Guangxun Gao, Zeping Zhou, Yaozhu Pan, Ying Sun, Hong Zhang, Zhiqiang Liu, Yanping Ma, Yi Wang, Wei Sun, Jian Hou, Jian‐Qing Mi, Wen-Ming Chen, Xiaobing Huang, Bing-Zong Li, Rong Fu, Jumei Shi, Xuehong Ran, Fuling Zhou, Aili He, Min Mao, Zhen Cai, Nan Li, Meng Xu, Xiaojing Yan, Wei Yang, Gang An, Li-Hua Gong, Lichao Sun, Zhihong Li, Tang Liu, Yanjuan He, Junqiang Yin, Yao Liu, Weifeng Liu, Li Bao · 发表于：Cancer Pathogenesis and Therapy · 年份：2024 · DOI：10.1016/j.cpt.2024.12.002 · 被引用次数：4 · 研究领域：Multiple Myeloma Research and Treatments、Bone health and treatments、Management of metastatic bone disease

This consensus on multiple myeloma-related bone diseases (MBDs) underscores the importance of a multidisciplinary approach that encompasses hematology, radiology, orthopedics, and additional specialties to tackle its intricate challenges. MBD, a prevalent and debilitating complication of multiple myeloma, leads to bone pain, fractures, and skeletal-related events (SREs), which profoundly impact patients’ quality of life. The guidelines offer a thorough framework for diagnosis, treatment, and continual assessment, emphasizing early detection and consistent monitoring using imaging techniques such as positron emission tomography-computed tomography (PET-CT) and magnetic resonance imaging (MRI). Treatment strategies prioritize the careful application of anti-myeloma agents, bisphosphonates, and denosumab to minimize bone loss and decrease SRE risk, complemented by surgical and radiotherapy interventions for structural or pain-related issues. Supportive care measures, including pain management, rehabilitation, nutritional support, and dental evaluations, play a crucial role in enhancing patient outcomes and preserving quality of life. This consensus advocates a standardized, evidence-based approach to managing MBD, ensuring comprehensive and coordinated care for patients. • A multidisciplinary approach is essential for managing multiple myeloma-related bone disease (MBD). • MBD in myeloma causes pain, fractures, and skeletal-related events (SREs), lowering patients' quality of li...