Progress in the study of curcumin metabolism in vivo

作者：Shi-Jie Zhong, Yadong Xing, Lu-Yao Dong, Yi Chen, Nan Liu, Zeng-Ming Wang, Hui Zhang, Aiping Zheng · 发表于：Journal of Asian Natural Products Research · 年份：2024 · DOI：10.1080/10286020.2024.2420619 · 被引用次数：15 · 研究领域：Curcumin's Biomedical Applications、Biochemical effects in animals、Natural product bioactivities and synthesis

Curcumin has diverse biological functions, especially antioxidant and anti-inflammatory properties, but clinical trials have been hindered by its low bioavailability and pharmacokinetic properties. To achieve therapeutic efficacy, understanding curcumin’s in vivo metabolism is crucial. We reviewed current research on curcumin metabolism in PubMed, Google Scholar, and CNKI. This article outlines curcumin’s metabolic processes in the body via oral and intravenous injection. It suggests that upon entering the human body, curcumin may undergo oxidation, reduction, binding, and microbial community influence.