Shedding light on vascular imaging: the revolutionary role of nanotechnology

作者：Peisen Zhang, Li Yao, Xiaoqi Li, Yudong Wang, Lin Hua, Ni Zhang, Wenyue Li, Lihong Jing, Mingxia Jiao, Xiliang Luo, Yi Hou · 发表于：Journal of Nanobiotechnology · 年份：2024 · DOI：10.1186/s12951-024-03042-x · 被引用次数：10 · 研究领域：Nanoplatforms for cancer theranostics、Advanced Nanomaterials in Catalysis、Cerebrovascular and Carotid Artery Diseases

Vascular dysfunction, characterized by changes in anatomy, hemodynamics, and molecular expressions of vasculatures, is closely linked to the onset and development of diseases, emphasizing the importance of its detection. In clinical practice, medical imaging has been utilized as a significant tool in the assessment of vascular dysfunction, however, traditional imaging techniques still lack sufficient resolution for visualizing the complex microvascular systems. Over the past decade, with the rapid advancement of nanotechnology and the emergence of corresponding detection facilities, engineered nanomaterials offer new alternatives to traditional contrast agents. Compared with conventional small molecule counterparts, nanomaterials possess numerous advantages for vascular imaging, holding the potential to significantly advance related technologies. In this review, the latest developments in nanotechnology-assisted vascular imaging research across different imaging modalities, including contrast-enhanced magnetic resonance (MR) angiography, susceptibility-weighted imaging (SWI), and fluorescence imaging in the second near-infrared window (NIR-II) are summarized. Additionally, the advancements of preclinical and clinical studies related to these nanotechnology-enhanced vascular imaging approaches are outlined, with subsequent discussion on the current challenges and future prospects in both basic research and clinical translation.