Selenomethionine alleviates T-2 toxin-induced articular chondrocyte ferroptosis via the system Xc−/GSH/GPX4 axis

作者：Fangfang Yu, Juan Zuo, Miao Wang, Shui-yuan Yu, Kangting Luo, Tong-tong Sha, Quan Li, Zai-chao Dong, Guoyu Zhou, Feng Zhang, Xiong Guo, Yue Ba, Yanjie Wang · 发表于：Ecotoxicology and Environmental Safety · 年份：2024 · DOI：10.1016/j.ecoenv.2024.117569 · 被引用次数：22 · 研究领域：Cancer-related molecular mechanisms research、Extracellular vesicles in disease、Ferroptosis and cancer prognosis

/GSH/GPX4 axis, thereby antagonizing ferroptosis of chondrocytes and alleviating articular cartilage damage. In conclusion, our findings highlight the essentiality of ferroptosis in chondrocyte caused by T-2 toxin, elucidate how Se-Met offers protection against this injury and provide research evidence for the drug treatment target of Kashin-Beck disease.