Hepatolithiasis pathogenesis update

作者：Wei Lü, Zhiyuan Li, Zhiming Yang, Jingcheng Hao · 发表于：Hepatology Research · 年份：2024 · DOI：10.1111/hepr.14153 · 被引用次数：6 · 研究领域：Gallbladder and Bile Duct Disorders、Pediatric Hepatobiliary Diseases and Treatments、Biliary and Gastrointestinal Fistulas

Hepatolithiasis is prevalent in East Asian countries and not common in Western countries. In recent years, because of the increased number of immigrants from East Asia in Western countries, hepatolithiasis has gradually become a global problem. Although current surgical interventions for hepatolithiasis boast a high rate of stone clearance, the persistent challenges of the disease's refractory nature and high recurrence rate continue to complicate its treatment. Therefore, understanding its underlying pathogenesis is meaningful for effective treatment. In this review, we discuss the common risk factors: infection, cholangitis, environmental factors and diet habits, abnormal bile components, anatomical abnormalities, and bile stasis, and summarize the relevant mechanisms.