A FET-based flexible biosensor system for dynamic behavior observation of lipid membrane with nanoparticles in vitro

作者：Keyi Zhu, Hanjing Lu, Qiannan Xue, Feng Zhou, Wenlan Guo, Chen Sun, Xuexin Duan · 发表于：Lab on a Chip · 年份：2024 · DOI：10.1039/d4lc00801d · 被引用次数：5 · 研究领域：Lipid Membrane Structure and Behavior、Electrochemical sensors and biosensors

to simulate the interaction between nanoparticles and lipid membranes under active conditions, with the aim of investigating the effect of differently sized nanoparticles on the cell membrane. The experimental results revealed that nanoparticles with a diameter smaller than 50 nm tend to induce mild strain and repairable damage to the membrane, whereas nanoparticles larger than 50 nm may cause more severe damage, and even transmembrane penetration, by creating unrecoverable pores. The stretching of the lipid membrane exacerbated the deformation and destruction caused by nanoparticles, even in the case of smaller particles. These above results are consistent with previous theories on the interactions between cell membranes and nanoparticles. The proposed biosensors provide a valuable tool for investigating how the nanosize dimensions of particles affect their ability to penetrate and cause destruction in dynamic cell membranes, contributing to the improvement of a more comprehensive theoretical system for understanding the interaction process between nanoparticles and cell membranes.