Evaluation of left atrial function and the relationship between left atrial stiffness index and exercise capacity in hypertension-related heart failure with preserved ejection fraction

作者：Qingfeng Zhang, Sijia Wang, Hongmei Zhang, Kai Wang, Wenhua Li, Geqi Ding, Luwei Ye, Chunmei Li, Yan Deng, Yi Wang, Lixue Yin · 发表于：Frontiers in Cardiovascular Medicine · 年份：2024 · DOI：10.3389/fcvm.2024.1501004 · 被引用次数：6 · 研究领域：Cardiovascular Function and Risk Factors、Cardiovascular Disease and Adiposity、Cardiac Fibrosis and Remodeling

Objective The left atrial stiffness index (LASI) holds significance in the atrioventricular coupling function and heart failure progression. To assess left atrial function and evaluate the relationship between LASI and exercise capacity in hypertension-related heart failure with preserved ejection fraction (HT-HFpEF). Methods The study involved 62 healthy subjects and 163 patients with HT (112 patients in simple HT group and 51 patients in HT-HFpEF group). Each patient performed exercise stress test and standard ultrasonic images were evaluated. A comprehensive evaluation of atrioventricular function, along with investigation into the correlation between these functional parameters and exercise capacity. And further to investigate the feasibility of predicting exercise intolerance using three-dimensional derived left atrial strain index (LASI) (E/e'/LASr and E/e'/LASr-c). Results Compared to healthy subjects, HT group demonstrated the elevation in left atrial volume accompanied by decrease in strain value ( P < 0.05). In HT-HFpEF group, further significant reductions were observed in both longitudinal (LASr) and circumferential strain (LASr-c, LASct-c) ( P < 0.05). Univariate regression demonstrated that both E/e'/LASr and E/e'/LASr-c were significantly correlated with metabolic equivalents (METs) (r = −0.462, P < 0.001; r = −0.381, P < 0.001). The E/e'/LASr demonstrates comparable diagnostic efficacy to exercise-E/e' in assessing exercise intolera...