Engineering Dual Active Sites and Defect Structure in Nanozymes to Reprogram Jawbone Microenvironment for Osteoradionecrosis Therapy

作者：Zheng Cheng, Yuchen Wang, Yuchen Wang, Haobo Lin, Ziyu Chen, Ran Qin, Tianxiao Wang, Hang Xu, Yifei Du, Hua Yuan, Yongchu Pan, Huijun Jiang, Xinquan Jiang, Jian‐Dong Jiang, Fan Wu, Yuli Wang, Yuli Wang · 发表于：Advanced Science · 年份：2024 · DOI：10.1002/advs.202413215 · 被引用次数：18 · 研究领域：Advanced Nanomaterials in Catalysis、Nanoplatforms for cancer theranostics、Advanced biosensing and bioanalysis techniques

Abstract Four to eight percent of patients with head and neck cancer will develop osteoradionecrosis of the jaw (ORNJ) after radiotherapy. Various radiation‐induced tissue injuries are associated with reactive oxygen and nitrogen species (RONS) overproduction. Herein, Fe doping is used in VO x (Fe‐VO x ) nanozymes with multienzyme activities for ORNJ treatment via RONS scavenging. Fe doping can induce structure reconstruction of nanozymes with abundant defect production, including Fe substitution and oxygen vacancies (OVs), which markedly increased multiple enzyme‐mimicking activity. Catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) enzyme‐like performance of Fe‐VO x can effectively reprogram jawbone microenvironment to restore mitochondrial dysfunction and enhance mitophagy. Moreover, the surface plasmon resonance (SPR) effect of Fe‐VO x made it a good photothermal nanoagents for inhibiting jaw infection. Thus, this work demonstrated that Fe‐VO x nanozymes can efficiently scavenge RONS, activate mitophagy, and inhibit bacteria, which is potential for ORNJ treatment.