Identification of Predictors of Shift Work Adaptation and Its Association With Immune, Hormonal and Metabolite Biomarkers

作者：Barbara N Harding, Ana Espinosa, Gemma Castaño‐Vinyals, Óscar J. Pozo, Debra J. Skene, Mariona Bustamante, María Jesús Rubiera Mata, Ruth Aguilar, Carlota Dobaño, Valentin Wucher, José Maria Navarrete, Patricia Such Faro, Antonio Torrejón, Manolis Kogevinas, Kyriaki Papantoniou · 发表于：Journal of Pineal Research · 年份：2024 · DOI：10.1111/jpi.70017 · 被引用次数：7 · 研究领域：Circadian rhythm and melatonin、Sleep and Work-Related Fatigue、Thermoregulation and physiological responses

We explored predictors of shift work adaptation and how it relates to disease risk biomarker levels. These analyses included 38 male, rotating shift workers, sampled twice at the end of a 3-week night shift and a 3-week day shift rotation. Participants collected all 24-h urine voids, wore activity sensors, and responded to questionnaires during each shift. Using cosinor analysis, we derived the main period of urinary 6-sulfatoxymelatonin (aMT6s) production. Adaptation was defined as the overlap between the main aMT6s production period and sleep period assessed with actigraphy. We used linear models to identify predictors of adaptation to each shift and assessed associations between adaptation profiles and hormone, cytokine, and metabolite biomarker levels. The median duration of overlap (adaptation) was 3.85 h (IQR 2.59-5.03) in the night and 2.98 (IQR 2.17-4.11) in the day shift. In the night shift, a later chronotype (coeff: -1.16, 95% CI -1.87, -0.45) and increased light at night (coeff: -0.97, 95% CI -1.76, -0.18) were associated with poorer adaptation, while longer sleep duration was associated with better adaptation (coeff: 0.46, 95% CI 0.04, 0.88). In the day shift, later sleep onset was associated with worse adaptation (coeff: -0.06, 95% CI -0.12, -0.01), while longer sleep duration was associated with better adaptation (coeff: 0.54, 0.26, 0.81). Results suggest higher androgen and inflammatory marker levels and lower levels of several metabolite markers among less ad...