Novel full-thickness biomimetic corneal model for studying pathogenesis and treatment of diabetic keratopathy

作者：Zekai Cui, Xiaoxue Li, Yiwen Ou, Xihao Sun, Jianing Gu, Chengcheng Ding, Zhexiong Yu, Yonglong Guo, Yuqin Liang, Shengru Mao, Jacey Hongjie, Hon Fai Chan, Shibo Tang, Jiansu Chen · 发表于：Materials Today Bio · 年份：2024 · DOI：10.1016/j.mtbio.2024.101409 · 被引用次数：5 · 研究领域：Corneal surgery and disorders、Corneal Surgery and Treatments、Glaucoma and retinal disorders

models. Notably, LBGP suppressed the expression of CCL5, highlighting its potential mechanism of action. This study establishes a robust biomimetic platform for investigating DK and other corneal diseases, and identifies LBGP as a promising therapeutic candidate for DK. These findings provide valuable insights into corneal disease mechanisms and pave the way for future translational research and clinical applications.