Epigenetic modifications and emerging therapeutic targets in cardiovascular aging and diseases

作者：Yurou Qiu, Qing Xu, Peng Xie, Chao He, Qiuchan Li, Xin Yao, Yang Mao, Xiaoqian Wu, Tiejun Zhang · 发表于：Pharmacological Research · 年份：2024 · DOI：10.1016/j.phrs.2024.107546 · 被引用次数：28 · 研究领域：Epigenetics and DNA Methylation、Histone Deacetylase Inhibitors Research、Genetics and Neurodevelopmental Disorders

A), in cardiovascular pathogenesis is also discussed. We summarize potential therapeutic targets, such as key enzymes and their inhibitors, including DNMT inhibitors like 5-azacytidine and decitabine, HDAC inhibitors like belinostat and givinotide, some of which have been approved by the FDA for various malignancies, suggesting their potential in treating cardiovascular diseases. Furthermore, we highlight the role of novel histone modifications and their associated enzymes, which are emerging as potential therapeutic targets in cardiovascular diseases. Thus, by incorporating the recent studies involving patients with cardiovascular aging and diseases, we aim to provide a more detailed and updated review that reflects the advancements in the field of epigenetic modification in cardiovascular diseases.