Polymeric nanoparticles in radiopharmaceutical delivery strategies

作者：Haidong Tian, Huijun Guo, Jiadi Liu, Yonghua Du, Haiwei Ren, Hongyan Li · 发表于：Journal of Materials Chemistry B · 年份：2024 · DOI：10.1039/d4tb02076f · 被引用次数：6 · 研究领域：Radiopharmaceutical Chemistry and Applications、Chemical Synthesis and Characterization、Thermodynamic and Structural Properties of Metals and Alloys

active targeting, passive targeting and stimuli-responsive release systems. The objective is to deliver drugs and nuclides to the target site in an efficient manner, thereby maximizing efficacy and minimizing side effects. The development of drug release systems has the potential to address the growing social and economic challenges currently facing modern healthcare. This paper presents a detailed synthesis of the methods used to create polymer nanoparticles (NPs) and strategies for the targeted delivery of radiopharmaceuticals with radionuclides labelled at different locations. Additionally, the paper outlines the current progress of polymer NPs for use in imaging and therapeutic applications, as well as the future challenges that lie ahead in this field.