Association of multiple environmental exposures with rhinitis and asthma symptoms in preschool children: Identifying critical risk factor

作者：Shuang Du, Hao Tang, Han Chen, Yang Shen, Zhiping Niu, Tianyi Chen, Jing Wei, Xia Meng, Wen Su, Qun Wu, Yongqiang Tan, Jing Cai, Zhuohui Zhao · 发表于：Ecotoxicology and Environmental Safety · 年份：2024 · DOI：10.1016/j.ecoenv.2024.117490 · 被引用次数：3 · 研究领域：Allergic Rhinitis and Sensitization、Asthma and respiratory diseases、Pediatric health and respiratory diseases

The concept “one airway, one disease” for childhood rhinitis and asthma has been challenged in recent years. This study aimed to evaluate associations of environmental exposures with alone and co-morbid symptoms of rhinitis and asthma and identify critical risk factor. 5828 children aged 3–6 years in Shanghai were surveyed in 2019. Rhinitis and wheezing symptoms in the past 12 months were collected using questionnaire. 11 outdoor environment exposure factors were assessed by high-resolution spatial-temporal model based on residences. Logistic regression and random forest were applied to evaluate and rank the association of environmental exposure with rhinitis and wheezing symptoms. The proportions of children with rhinitis alone, wheezing & rhinitis, and wheezing alone were 37.2 %, 4.6 %, and 2.6 %, respectively. Regression modeling of two exposure factors adjusted for each other showed that PM 1 , PM 2.5 and nighttime light(NTL) remained the robust significant associations with rhinitis alone, whereas NO 2 had the robust significant association with wheezing & rhinitis and wheezing alone. Random forest ranking analysis further corroborated the most significant environmental exposure for rhinitis alone was PM 1 , and for wheezing symptoms (both wheezing & rhinitis and wheezing alone) was NO 2 . Significant additive and multiplicative interactions were examined between indoor dampness and PM 1 exposure on rhinitis alone. Children’s current rhinitis alone was more susceptible t...