Patient-Reported Outcomes for Low-Risk Ductal Carcinoma In Situ

作者：Ann H. Partridge, Terry Hyslop, Shoshana M. Rosenberg, Antonia Vickery Bennett, Sarah Drier, Mattias Jönsson, Ayako Shimada, Yutong Li, Yan Li, Thomas Hugh Lynch, Elizabeth Frank, Deborah E. Collyar, Desiree Basila, Donna Pinto, Anna Weiss, Anna D. Wolf, Kelsey Norris, Meredith Witten, Marc E. Boisvert, Armando E. Giuliano, Kelsey E. Larson, Kathleen J. Yost, Priscilla F. McAuliffe, Amy K. Krie, Nina Tamirisa, Sonja Darai, Lisa A. Carey, Alastair Mark Thompson, E. Shelley Hwang, Vinay K. Gudena, Akiko Chiba, Jessica Miley Bensenhaver, Eleni Andreopoulou, Elizabeth Ann Mittendorf, Cindy Brown Matsen, Rubie Jackson, Deba P. Sarma, Elie G. Dib, Heather B. Neuman, Tina W. F. Yen, Doreen Marie Agnese, Rachelle Leong, Patricia A. Cronin, Ingrid M. Lizarraga, Joseph Michael Guenther, Kristalyn K. Gallagher, Reema Batra, Ann Marilyn Leitch, Timothy M. Moore, Kimberly S. Strickland, Moira Christoudias, Marissa Michelle Howard-McNatt, Anna M. Higham, Anasuya Gunturi, John M. Schallenkamp, Karng Log, Samantha Andrews Seaward, Heather M. N. Wright, Amy Rivere, Eric Feliberti, Lisa Ann Lai, Jessica Cintolo-Gonzalez, Kandace P. McGuire, Ki Young Chung, Anjali R. Thawani, Emily Marcinkowski, Jennifer L. Marti, Nathalie A. Johnson, Sandhya Pruthi, April Phantana-angkool, Jessica E. Maxwell, Sangeetha Prabhakaran, Douglas Jay Weckstein, Mahvish Muzaffar, Sarah Sinclair, Christopher M. McGreevy, Steve Madden, Laura Peterson, Dan Sotirescu, Hannah W Hazard-Jenkins, Thomas E. Lad, Sarah A. McLaughlin, Sheldon Marc Feldman, Matthias Weiss, Suliat M. Nurudeen, M. Firdos Ziauddin, Anthony John Jaslowski, Ivy Elizabeth Abraham, Faith Goldman, Nicholas J. DiBella, Mehra A. Golshan, Tuoc Dao, Howard M. Gross, Yolanda Tammaro, Mindy Bowie, Katharine A. Yao, Theodore Kim, Rebecca Aft, Alyssa D. Throckmorton, Jose Eugenio Najera, Lisa Yee, Jennifer Christman, Shylendra B Sreenivasappa, Huong T. Le‐Petross, Rachel E. Factor, Jeffrey R. Marks, Elissa M. Ozanne, Rinaa Sujata Punglia, Jennifer M. Gierisch, Lola Fayanju, Celia Patricia Kaplan, Laura Colletti, Wendy Stewart, Mary Lou Smith, Joann G. Elmore, Lynn A. Bowlby, Constance Dobbins Lehman, Stuart J. Schnitt, Henry Keurer, Deanna J. Attai, Patricia A. Ganz, Craig C. Earle, Karla M. Kerlikowske, Ruth Etzioni, Rosemarie B. Hakim, Jennifer K. Malin, Carol S. Palackdharry, David Webster, Richard L. Schilsky, Robert Allen Smith, Coralia Calomeni, Jessica A. Wernberg, Ellis Glenn Levine, Gary Walter Unzeitig, Kenneth M. Manning, Chiara Battelli, William M Dooley, Trupti Hattiangadi, Ann M. Mauer, Angela Marie Mislowsky, Jean J. Bao, Anne Hudson Blaes, Theresa A. Graves, Robert J. Behrens, Kerry Pulver, Walid El Ayass, Seth Miller · 发表于：JAMA Oncology · 年份：2024 · DOI：10.1001/jamaoncol.2024.6556 · 被引用次数：16 · 研究领域：Breast Cancer Treatment Studies、Global Cancer Incidence and Screening、Lung Cancer Diagnosis and Treatment

Importance: Active monitoring (AM) for low-risk ductal carcinoma in situ (DCIS) has been considered as a potential alternative to guideline-concordant care (GCC; inclusive of surgery with or without radiation). Reported data comparing patient-reported outcomes (PROs) between GCC and AM for DCIS are lacking. Objective: To compare PROs at baseline and over time in patients with low-risk DCIS randomized to receive either AM or GCC. Design, Setting, and Participants: This prespecified secondary outcome analysis used prospectively collected validated questionnaires at baseline, 6 months, 1 year, and 2 years from participants enrolled from June 2017 to January 2023 in the Comparing an Operation to Monitoring, With or Without Endocrine Therapy (COMET) study for low-risk DCIS, which randomized participants to receive GCC or AM. Intervention: Randomization to GCC or AM. Main Outcomes and Measures: Context-relevant PROs, including health-related quality of life, anxiety, depression, and symptoms measured by validated survey instruments. Mixed models, including sensitivity analyses, with group, point, and group-by-point effects were used to compare PROs between groups. Results: Of the 957 participants in COMET, 225 (24%) were younger than 55 years at enrollment, 325 (34%) were aged 55 to 65 years, and 403 (42%) were older than 65 years, and 953 (99.5%) completed questionnaires at some point within the first 2 years, with a completion rate of more than 83% at all points. Quality of life,...