Traumatic Brain Injury and Risk of Incident Comorbidities

作者：Cathra Halabi, Saef Izzy, Anthony M. DiGiorgio, Hunter Mills, Farid Radmanesh, John K. Yue, Habibeh Ashouri Choshali, Gundolf Schenk, Sharat Israni, Ross Zafonte, Geoffrey T. Manley · 发表于：JAMA Network Open · 年份：2024 · DOI：10.1001/jamanetworkopen.2024.50499 · 被引用次数：26 · 研究领域：Traumatic Brain Injury Research、Traumatic Brain Injury and Neurovascular Disturbances、Trauma and Emergency Care Studies

Importance: Traumatic brain injury (TBI) is associated with chronic medical conditions. Evidence from diverse clinical administrative datasets may improve care delivery. Objective: To characterize post-TBI risk of incident neuropsychiatric and medical conditions in a California health care system administrative database and validate findings from a Massachusetts dataset. Design, Setting, and Participants: In this cohort study, prospective longitudinal cohorts using data from 5 University of California health care settings between 2013 and 2022 were studied. Patients aged 18 years and older with mild (mTBI) or moderate to severe TBI (msTBI) were included. Unexposed individuals were propensity matched by age, race and ethnicity, sex, University of California site, insurance coverage, area deprivation index (ADI) score, and duration from index date to most recent clinical encounter. Patients with study comorbidities of interest before the index date were excluded. Data were analyzed August to October 2024. Exposure: TBI. Main Outcomes and Measures: International Classification of Diseases, Ninth Revision (ICD-9) and International Statistical Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) codes were used to identify patients with TBI and patients with up to 22 comorbidities within neurological, psychiatric, cardiovascular, and endocrine umbrella groupings. Cox proportional hazard models were used to generate yearly hazard ratios (HRs) from 6 months ...