Three-year Survival Outcomes of Patients With Enhanced Recovery After Surgery Versus Conventional Care in Laparoscopic Distal Gastrectomy

作者：Yulong Tian, Shougen Cao, Leping Li, Wenbin Yu, Yinlu Ding, Guangyong Zhang, Lixin Jiang, Jianjun Qu, Hao Wang, Xinjian Wang, Weizheng Mao, Huanhu Zhang, Xianqun Chu, Xizeng Hui, Dongfeng Zhang, Zhaojian Niu, Changqing Jing, Haitao Jiang, Xiaodong Liu, Zequn Li, Henrik Kehlet, Yanbing Zhou, on behalf of the Shandong Gastrointestinal Surgery Study Group (GISSG) · 发表于：Annals of Surgery · 年份：2024 · DOI：10.1097/sla.0000000000006603 · 被引用次数：13 · 研究领域：Enhanced Recovery After Surgery、Gastric Cancer Management and Outcomes、Dietary Effects on Health

OBJECTIVE: The efficacy of enhanced recovery after surgery (ERAS) to improve the prognosis of patients who undergo laparoscopic distal gastrectomy (LDG) for gastric cancer is uncertain. This randomized study compared oncological outcomes in LDG after ERAS or conventional care. BACKGROUND: At present, randomized controlled trials have confirmed that ERAS can improve the short-term clinical outcomes of patients undergoing LDG, but whether it improves survival has not been reported yet. METHODS: A multicenter, randomized, controlled trial was performed to compare oncological outcomes of ERAS versus conventional care in LDG. Between April 4, 2019 and March 18, 2020, 527 patients with locally advanced lower gastric adenocarcinoma were recruited from 13 centers in China. The primary endpoints were 3-year overall survival (OS) and disease-free survival (DFS). The secondary endpoints were complications, mortality, recovery, time of receiving adjuvant chemotherapy, and medical expenses. RESULTS: The full analysis set included 186 cases in the ERAS group and 184 in the conventional group, well balanced with respect to patient demographics and baseline characteristics (published before). Postoperative hospital stay and the interval before adjuvant chemotherapy were obviously shorter in the ERAS group compared with the conventional group as reported previously and with lower medical expenses. Compared with the conventional group, the ERAS group had fewer overall complications (21.0% vs 3...