Research on the mechanism of core acupoints in electroacupuncture for functional constipation based on data mining and network acupuncture

作者：S. Ong, Ting Tang, Lianjie Xu, Chao Xu, Qi Li, Xiaoyue Deng, Peihua Shen, Yi Chen, Yang Song, Hai Lü, Ling Fang · 发表于：Frontiers in Medicine · 年份：2024 · DOI：10.3389/fmed.2024.1482066 · 被引用次数：11 · 研究领域：Gastrointestinal motility and disorders、Acupuncture Treatment Research Studies、Traditional Chinese Medicine Studies

Aim: Functional Constipation (FC) is a common gastrointestinal disorder that imposes a considerable strain on global health. It negatively impacts the quality of life and results in significant healthcare expenditures. Current treatments, such as lifestyle changes and medications, fail to meet patient satisfaction due to efficacy and safety issues. Electroacupuncture (EA), with its precise stimulation control and standardized protocols, shows promise in FC management. However, optimal EA parameters for FC treatment are yet to be established. Our study reviews EA applications in FC to inform a standardized treatment approach and explore EA's therapeutic mechanisms. Methods: This comprehensive study utilized research literature from databases including PubMed, Embase, OVID, Web of Science, the Cochrane Library, CNKI, VIP, and Wanfang to perform a descriptive analysis of acupoint selection and EA parameters. It proceeded to analyze high-frequency acupoint groupings and stimulus parameters, followed by the excavation and analysis of core acupoint prescriptions. Subsequent steps integrated potential target identification for these core formulas, the assembly of a "core acupoint-prescription-target-constipation" network, and the construction of a protein-protein interaction (PPI) network to extract central targets. Additionally, Gene Ontology (GO) and KEGG enrichment analyses were conducted to prognosticate the underlying mechanisms by which EA may exert its therapeutic effects on ...