Design, construction and validation of a magnetic particle imaging (MPI) system for human brain imaging

作者：Eli Mattingly, Monika Śliwiak, Erica E. Mason, Jorge Chacon‐Caldera, Alex Barksdale, Frauke H Niebel, Konstantin Herb, Matthias Gräser, Lawrence L. Wald · 发表于：Physics in Medicine and Biology · 年份：2024 · DOI：10.1088/1361-6560/ad9db0 · 被引用次数：37 · 研究领域：Characterization and Applications of Magnetic Nanoparticles、Geomagnetism and Paleomagnetism Studies、Microfluidic and Bio-sensing Technologies

Abstract Objective. Magnetic particle imaging (MPI) was introduced in 2005 as a promising, tracer-based medical imaging modality with the potential for high sensitivity and spatial resolution. Since then, numerous preclinical devices have been built but only a few human-scale devices, none of which targeted functional neuroimaging. In this work, we probe the challenges of scaling the technology to meet the needs of human functional neuroimaging with sufficient sensitivity for detecting the hemodynamic changes following brain activation with a spatio-temporal resolution comparable to current functional magnetic resonance imaging approaches. Approach. We built a human brain-scale MPI system using a mechanically-rotated, permanent-magnet-based field-free line (FFL) ( 1.1 Tm − 1 ) with a water-cooled, 26 kHz drive coil producing a field of up to 7 mT peak , and receive coil that can fit over a human head. Images are acquired continuously at a temporal resolution of 5 s/image, controlled by in-house LabView-based acquisition software with online reconstruction. We used a dilution series to quantify the detection limit, a series of parallel-line phantoms to assess the spatial resolution, and a large ‘G’ shaped phantom to demonstrate the human-scale field of view (FOV). Main results. The imager has a sensitivity of about 1 µ g Fe over a 2D imaging FOV of 181 mm diameter(132 pixels) in...