Anti-diabetic therapies on dental implant success in diabetes mellitus: a comprehensive review

作者：Hamzeh Ghorbani, Arsen Minasyan, Delaram Ansari, Parvin Ghorbani, David A. Wood, Rozi Yeremyan, Simin Ghorbani, Natali Minasian · 发表于：Frontiers in Pharmacology · 年份：2024 · DOI：10.3389/fphar.2024.1506437 · 被引用次数：34 · 研究领域：Dental Implant Techniques and Outcomes、Bone health and osteoporosis research、Oral microbiology and periodontitis research

Background and Objective: Dental implant therapy faces challenges in patients with Type 1 and Type 2 Diabetes Mellitus (T1DM and T2DM) due to adverse effects on bone metabolism and immune response. Despite advancements, diabetic patients face higher risks of peri-implantitis and compromised osseointegration. This review assesses the impact of anti-diabetic medications on implant outcomes, offering insights to bridge the gap between animal studies and clinical practice. By evaluating pharmacotherapeutic strategies in preclinical models, this review guides future research designs to improve implant success rates in diabetic individuals. Method: A comprehensive literature review identified 21 animal studies examining the impact of anti-diabetic medications on dental and bone implants. These studies explored diabetes models, medication regimens, and designs to assess outcomes related to bone metabolism, osseointegration, and peri-implant tissue responses. The findings are systematically summarized, highlighting the scope, design, and procedures of each study. An example includes placing a dental implant in the molar region of a mouse, providing insight into preclinical approaches. Results: Twenty-one animal studies, primarily using rodents, investigate various anti-diabetic medications on dental and bone implants. Interventions include insulin, aminoguanidine, voglibose, sitagliptin, exenatide, and metformin, analyzing outcomes like bone-implant contact (BIC), bone volume (BV), a...