Effectiveness and safety of acupuncture for cancer-related hiccups: a systematic review and meta-analysis

作者：Zining Guo, Ying Liang, Wenhao Liu, Bingjing Huang, Huiyan Zheng, Shaoyang Cui, Nenggui Xu · 发表于：Frontiers in Neurology · 年份：2024 · DOI：10.3389/fneur.2024.1480656 · 被引用次数：7 · 研究领域：Pathogenesis and Treatment of Hiccups、Acupuncture Treatment Research Studies、Pain Management and Placebo Effect

Background The use of acupuncture in cancer treatment is expanding. Nevertheless, the efficacy and safety of acupuncture in alleviating cancer-related hiccups remains uncertain and inconclusive. Methods We conducted a systematic search across eight databases: PubMed, China National Knowledge Infrastructure Database, WanFang, China Science and Technology Journal Database, SinoMed, Web of Science, Cochrane, and Embase, covering the period from their inception to July 2023. Literature was screened based on predefined PICOS inclusion and exclusion criteria, and the risk of bias was assessed using the Cochrane Risk of Bias tool. Data synthesis was performed using Review Manager 5.3 software and R studio 4.4. Additionally, we conducted a frequency analysis of acupoint usage. Results A total of nine randomized controlled trials (RCTs) involving 580 patients were included in the analysis. The risk of bias assessment indicated a high risk of bias in all nine RCTs, primarily due to blinding of participants and personnel and random sequence generation (selection bias). The meta-analysis revealed that acupuncture significantly reduced the symptoms of cancer-related hiccups compared to pharmacological treatment (relative risk (RR) = 1.83, 95% confidence interval (CI) [1.53, 2.20], p < 0.001 , I 2 = 27%). In terms of onset time, acupuncture demonstrated a shorter duration of onset compared to pharmacological treatment (mean difference (MD) = −8.71, 95% CI [−23.32 5.89], p < 0...