Altered intra- and inter-network functional activity among migraine, chronic migraine, and trigeminal neuralgia

作者：Qichen Zhou, Rong Zhao, Zhaoxia Qin, Yapeng Qi, Weijun Tang, Lan Liu, Weikan Wang, Jian‐Ren Liu, Xiaoxia Du · 发表于：Molecular Pain · 年份：2024 · DOI：10.1177/17448069241300939 · 被引用次数：5 · 研究领域：Migraine and Headache Studies、Trigeminal Neuralgia and Treatments、Functional Brain Connectivity Studies

OBJECTIVE: This study aimed to investigate the specific manifestations and differences in brain network activity and functional connectivity between brain networks in patients with trigeminal neuralgia and migraine, aiming to reveal the neural basis of these two diseases. BACKGROUND: Head and facial pain, including trigeminal neuralgia and migraine, is prevalent globally. However, the underlying neural mechanisms of these conditions remain unclear. Resting-state functional connectivity studies based on independent component analysis (ICA) may offer new insights into these diseases. METHODS: The study involved 23 chronic migraine, 37 episodic migraine, 21 trigeminal neuralgia patients, and 33 age- and gender-matched controls. Resting-state functional magnetic resonance imaging was performed, and five sets of brain network components were extracted through ICA. Neuronal activity indicators were calculated for each participant's independent components, including amplitudes of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo). Functional connectivity was also assessed and compared among the four groups. RESULTS: Trigeminal neuralgia patients showed reduced ALFF in the dorsal attention network versus episodic migraine patients and controls. Both trigeminal neuralgia and chronic migraine patients had decreased ReHo in this network. Migraine patients had weaker connectivity between the default mode and visual networks than controls. Trigeminal neuralgia patients also ...