The increasing burden of group B Streptococcus from 2013 to 2023: a retrospective cohort study in Beijing, China

作者：Yingxing Li, Wenhang Yang, Yi Li, Kexin Hua, Ying Zhao, Tao Wang, Lingli Liu, Yali Liu, Yao Wang, Wenjing Liu, L Zhang, Renyuan Zhu, Shu-Ying Yu, Hongli Sun, Hongtao Dou, Qiwen Yang, Yingchun Xu, Lina Guo · 发表于：Microbiology Spectrum · 年份：2024 · DOI：10.1128/spectrum.02266-24 · 被引用次数：8 · 研究领域：Neonatal and Maternal Infections、Streptococcal Infections and Treatments、Sepsis Diagnosis and Treatment

ABSTRACT Group B Streptococcus (GBS) is a leading pathogen responsible for fatal infections in newborns primarily due to vertical transmission from colonized mothers. Cases of invasive GBS infections in adults have also increased and attracted attention recently. To comprehensively understand the evolving burden of vaginal GBS carriage in pregnant and non-pregnant women, as well as the trends in invasive GBS diseases and antibiotic resistance in China, we conducted a retrospective study using data from a large tertiary hospital in Beijing from 2013 to 2023. Over the past decade, improvements in GBS screening methods for pregnant women have significantly increased the GBS recovery rate. The detection rate of GBS and its proportion among vaginal pathogens have shown a gradual increase in GBS colonization in both pregnant and non-pregnant women. An analysis of vaginal pathogen composition revealed variations in GBS prevalence across different age groups, as well as a potential competitive relationship between GBS and Enterococcus faecalis in the vaginal environment. Additionally, we analyzed 165 invasive GBS cases, including three in newborns. The incidence of invasive GBS cases has risen since 2016, particularly among individuals over the age of 40. The 5,858 GBS isolates exhibited notably high resistance rates to erythromycin (72.2%), clindamycin (60%), and levofloxacin (50.1%), with 30.8% classified as multidrug-resistant. Importantly, invasive GBS strains exhibited a higher ...