Perturbation of mRNA splicing in liver cancer: insights, opportunities and challenges

作者：Qi Jia, Xiaoxiao Sun, Haoyu Li, Jianglong Guo, Kongyan Niu, Kui Ming Chan, René Bernards, Wenxin Qin, Haojie Jin · 发表于：Gut · 年份：2024 · DOI：10.1136/gutjnl-2024-333127 · 被引用次数：9 · 研究领域：RNA Research and Splicing、RNA modifications and cancer、RNA and protein synthesis mechanisms

Perturbation of mRNA splicing is commonly observed in human cancers and plays a role in various aspects of cancer hallmarks. Understanding the mechanisms and functions of alternative splicing (AS) not only enables us to explore the complex regulatory network involved in tumour initiation and progression but also reveals potential for RNA-based cancer treatment strategies. This review provides a comprehensive summary of the significance of AS in liver cancer, covering the regulatory mechanisms, cancer-related AS events, abnormal splicing regulators, as well as the interplay between AS and post-transcriptional and post-translational regulations. We present the current bioinformatic approaches and databases to detect and analyse AS in cancer, and discuss the implications and perspectives of AS in the treatment of liver cancer.