Visible-Light-Mediated Nucleophilic Addition of Alkene with Aldehyde: Synthesis of Secondary Alcohols

作者：D. Hu, Haowen Dang, Zhen Liang, Donghao Wang, Yunyun Du, Chao Shen, Jiabin Shen, Min Wang · 发表于：Organic Letters · 年份：2024 · DOI：10.1021/acs.orglett.4c03819 · 被引用次数：16 · 研究领域：Radical Photochemical Reactions、Catalytic C–H Functionalization Methods、Sulfur-Based Synthesis Techniques

Herein, a photocatalytic strategy for the synthesis of secondary alcohols by nucleophilic addition of an alkene with an aldehyde is described. This operationally simple methodology opens an approach for the synthesis of alcohols using commercially available reagents in moderate to excellent yields. Mechanistic studies indicate that the formation of the radical anion from alkene via single-electron transfer is the key step in this reaction.